Beyond gene duplication: A-to-I RNA editing–mediated stop codon readthrough modulates Dbf2 dosage to resolve pleiotropic conflicts
and identify many stop-loss edits encoding destabilizing tails consistent with positive genome-wide selection. We propose that stage-specific stop-loss editing is a developmentally gated dosage-buffering mechanism that transiently reduces NDR kinase abundance during ascospore formation, thereby alleviating growth-reproduction trade-offs without requiring gene duplication.
Authors
- Qinhu Wang (ORCID: https://orcid.org/0000-0003-1251-073X)
- Cong Jiang (ORCID: https://orcid.org/0000-0002-5634-3200)
- Huiquan Liu (ORCID: https://orcid.org/0000-0002-4723-845X)
- Yanfei Du (ORCID: https://orcid.org/0009-0008-7473-5129)
- Mengchun Wu
- Y Zhang
- Chenhui Wang (ORCID: https://orcid.org/0000-0003-0932-3511)
- Mirong Hou
Institutions
- Northwest A&F University (CN)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1073/pnas.2532534123
- Primary Topic
- RNA and protein synthesis mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00