Autophagy Inhibition by <i>Fangji Huangqi Decoction</i> Enhances Tumor Immunogenicity and Potentiates <scp>PD</scp> ‐1 Blockade
T cell activity, increased granzyme B and IFN-γ expression, and induced substantial tumor regression. These findings demonstrate that FJHQ enhances antitumor immunity by suppressing autophagy and elevating MHC-I expression, thereby sensitizing tumors to PD-1 blockade. FJHQ represents a promising immunoadjuvant for cancer therapy.
Authors
- Dingye Wang
- DJ Chen
- Kun Wang (ORCID: https://orcid.org/0000-0003-3282-4330)
- Zhenzhen Li (ORCID: https://orcid.org/0000-0002-7035-6657)
- Jianyong Xiao (ORCID: https://orcid.org/0000-0003-1815-9127)
- Xiaoyi Liu (ORCID: https://orcid.org/0009-0006-5862-2031)
- Biaoyan Du
- X P Zhao
- J Li
- Fang Liu
- Qianwei Cai
- Qiaohong Yang
- Junbo Jiang
- Yuehua Deng
- Zheng Ying
- Silin Mai
- Shiji Zeng
- Yuxiao Jiang
- Jiayi Zheng
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Zhongshan Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cancer Science
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1111/cas.70399
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province