Self-cleavage-dependent and -independent functions of <i>Adgrg1/Gpr56</i> in mice
knockout mice, indicating that TA agonism is indispensable for proper cerebellar lobule formation and neuronal migration. TA-dependent signaling was also required for male mouse fertility, but not for adult cardiomyocyte homeostatic functions, platelet-dependent hemostasis, or axon myelination in the central nervous system. These findings indicate that GPR56 has multiple modes of activation and that these signaling outcomes are likely driven by NTF interactions with specific ligands including collagen and transglutaminase-2.
Authors
- Tyler F. Bernadyn (ORCID: https://orcid.org/0000-0002-1162-2425)
- Matthew J. Brody (ORCID: https://orcid.org/0000-0003-4904-7670)
- Riya Gandhi
- James P. Teuber (ORCID: https://orcid.org/0000-0001-5340-3290)
- Frank E. Kwarcinski
- Xinyi Lu (ORCID: https://orcid.org/0000-0003-2610-6084)
- Gregory G. Tall (ORCID: https://orcid.org/0000-0002-6540-4896)
- Ingrid L. Bergin (ORCID: https://orcid.org/0000-0001-5436-4633)
- Michael A. Holinstat (ORCID: https://orcid.org/0000-0001-5100-1933)
- Mariane Nascimento
- Tingzhen Shen
Institutions
- University of Michigan (US)
- Core Laboratories (United States) (US)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1073/pnas.2527832123
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of General Medical Sciences