Serum matrix metalloproteinase-7 as a diagnostic and prognostic biomarker in primary biliary cholangitis

Objectives: This study aimed to assess the diagnostic and prognostic value of serum matrix metalloproteinase-7 (MMP-7) in patients with primary biliary cholangitis (PBC). Methods: = 109) subgroups; 65 underwent liver biopsy with Ludwig classification. Liver function tests, platelet count, the aspartate aminotransferase-to-platelet ratio index (APRI), and fibrosis-4 index (FIB-4) were assessed. Diagnostic performance was evaluated via group comparisons, Spearman correlation, and receiver operating characteristic curve analysis. Results: < 0.01). After 3-4 months of ursodeoxycholic acid treatment, MMP-7 decreased significantly and paralleled alkaline phosphatase decline. Conclusion: Serum MMP-7 is elevated in PBC and correlates with disease severity, including cirrhosis and advanced fibrosis. It shows robust diagnostic performance as a standalone biomarker and demonstrates promise for monitoring treatment response, underscoring its potential clinical utility as a complementary non-invasive tool in PBC management.