Case Report: Pulmonary Mycobacterium avium complex mimicking recurrent tuberculosis in a patient with suspected pneumoconiosis and destroyed lung diagnosed by bronchoalveolar lavage fluid targeted next-generation sequencing

complex (349 sequence reads, 53.4% relative abundance). The patient's condition improved rapidly following a targeted multidrug regimen (clarithromycin, rifampicin, ethambutol, and amikacin) combined with supportive pneumoconiosis care. This case highlights the vital role of tNGS in differentiating nontuberculous mycobacterial disease from recurrent tuberculosis in patients with complex structural lung damage, enabling timely and precise intervention.

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Publication Details

Journal
Frontiers in Medicine
Published
2026-04-22
DOI
https://doi.org/10.3389/fmed.2026.1832417
Primary Topic
Mycobacterium research and diagnosis
Type
article
Field-Weighted Citation Impact
0.00
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article

Case Report: Pulmonary Mycobacterium avium complex mimicking recurrent tuberculosis in a patient with suspected pneumoconiosis and destroyed lung diagnosed by bronchoalveolar lavage fluid targeted next-generation sequencing

Lei Zha, Liqin Zhang, Chao Xie
Frontiers in Medicine
Mycobacterium research and diagnosis
article

Case Report: Pulmonary Mycobacterium avium complex mimicking recurrent tuberculosis in a patient with suspected pneumoconiosis and destroyed lung diagnosed by bronchoalveolar lavage fluid targeted next-generation sequencing

Lei Zha, Liqin Zhang, Chao Xie
article en

Abstract

complex (349 sequence reads, 53.4% relative abundance). The patient's condition improved rapidly following a targeted multidrug regimen (clarithromycin, rifampicin, ethambutol, and amikacin) combined with supportive pneumoconiosis care. This case highlights the vital role of tNGS in differentiating nontuberculous mycobacterial disease from recurrent tuberculosis in patients with complex structural lung damage, enabling timely and precise intervention.

Frontiers in MedicineVol. 13
First Affiliated Hospital of Wannan Medical College (CN)
Openalex Percentile: Top 22%
Mycobacterium research and diagnosis
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