Biofilm- and Spore-Disruptive Star-Shaped Poly( <scp>l</scp> -lysine)/Hyaluronic Acid Microgels for Targeted Oral Therapy of <i>Clostridioides difficile</i> Infection
microgels as a microbiota-sparing therapeutic that targets multiple stages of CDI pathogenesis─including spores and biofilms─and demonstrate their potential for clinical translation.
Authors
- Yuan‐Pin Hung (ORCID: https://orcid.org/0000-0003-1006-705X)
- I Shiuan Lin
- Jeng‐Shiung Jan (ORCID: https://orcid.org/0000-0002-8379-404X)
- Yu‐Fang Chen (ORCID: https://orcid.org/0000-0003-2872-0336)
- Jenn‐Wei Chen (ORCID: https://orcid.org/0000-0002-5433-5178)
- Ching‐Chi Lee (ORCID: https://orcid.org/0000-0002-4949-2742)
- C Y Chou
- Jing-Ting Lin
- Ting-Yen Wang
Institutions
- E-Da Hospital (TW)
- Sustainable Innovation (Sweden) (SE)
- Tainan Municipal Hospital (TW)
- National Cheng Kung University Hospital (TW)
- National Cheng Kung University (TW)
- I-Shou University (TW)
Publication Details
- Journal
- Biomacromolecules
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1021/acs.biomac.5c02037
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- E-Da Hospital
- National Cheng Kung University Hospital
- National Cheng Kung University
- National Science and Technology Council