Genetic determinants of fatigue up to 2 years after radiotherapy in prostate cancer patients

) are identified for distinct fatigue phenotypes. Gene expression differences are observed for ACTR3 and CBWD2, although not significant after correction for multiple testing. The results emphasise the multidimensionality of fatigue and suggest a plausible biological mechanism in fatigue pathophysiology, previously discussed for myalgic encephalomyelitis/chronic fatigue syndrome, which might be a potential intervention target.

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Publication Details

Journal
Nature Communications
Published
2026-04-22
DOI
https://doi.org/10.1038/s41467-026-72041-3
Primary Topic
Cancer survivorship and care
Type
article
Field-Weighted Citation Impact
0.00

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article

Genetic determinants of fatigue up to 2 years after radiotherapy in prostate cancer patients

Laura Torrado-Moya, Isabel Domínguez-Rios, J Chang-Claude, Paloma Sosa‐Fajardo et al.
Nature Communications
Cancer survivorship and care
article

Genetic determinants of fatigue up to 2 years after radiotherapy in prostate cancer patients

Laura Torrado-Moya, Isabel Domínguez-Rios, J Chang-Claude, Paloma Sosa‐Fajardo, Chris J. Talbot, Erik Briers, B. Avuzzi, Juan Fernández‐Tajes, Tim Rattay, A. Cicchetti, Liv Veldeman, D. Azria, Carsten Herskind, Adam Webb, Alison M. Dunning, Laura Fachal, Paula Peleteiro, Ulrich Giesche, Debbie Payne, P. Gabriele, T. Rancati, S. Morlino, Philipp Heumann, Ramón Lobato-Busto, E Sperk, Valérie Fonteyne, Holly Summersgill, Sara Gutiérrez‐Enríquez, Begoña Taboada‐Valladares, Gilles Defraene, Antonio Gómez‐Caamaño, Maarten Lambrecht, Miguel E. Aguado‐Barrera, Martina E. Schmidt, Harkeran K. Jandu, Petra Seibold, Irmgard Helmbold, Hilary Stobart, Marlon R. Veldwijk, Renée Bultijnck, Petra Stegmaier, Sarah Kerns, S. Vasanthan, R.P. Symonds, R. Kaaks, Roxana Draghici, Ben Vanneste, Catharine M. L.West, Richard Stock, Piet Ost, Olivia Fuentes-Ríos, Irene Fajardo-Paneque, Juan Camilo Rosas Romero, Belinda Rodriguez-Lage, Ana Carballo, Rebecca M. Shearer, Kiran Kancherla, Patricia Calvo-Crespo, Tim Ward, Christopher Kent, Ananya Choudhury, Dirk De Ruysscher, Barry S. Rosenstein, Karin Haustermans, Ana Vega, Riccardo Valdagni
article en

Abstract

) are identified for distinct fatigue phenotypes. Gene expression differences are observed for ACTR3 and CBWD2, although not significant after correction for multiple testing. The results emphasise the multidimensionality of fatigue and suggest a plausible biological mechanism in fatigue pathophysiology, previously discussed for myalgic encephalomyelitis/chronic fatigue syndrome, which might be a potential intervention target.

Nature CommunicationsVol. 17(1)
University of Leicester (GB), Inserm (FR), German Cancer Research Center (DE), University of Milan (IT), Université de Montpellier (FR), Medical College of Wisconsin (US), Heidelberg University (DE), University of Cambridge (GB), Ghent University Hospital (BE), University Hospital Heidelberg (DE), University Hospitals of Leicester NHS Trust (GB), Wellcome Sanger Institute (GB), Institut Agronomique Méditerranéen de Montpellier (FR), GZA Ziekenhuizen Campus Sint-Augustinus (BE), Complejo Hospitalario Universitario de Santiago (ES), Centro de Investigación Biomédica en Red (ES), St. Vincentius-Kliniken (DE), Universitätsklinik für Strahlentherapie (DE), Fundación Pública Galega de Medicina Xenómica (ES), The Christie NHS Foundation Trust (GB), Instituto de Investigación Sanitaria de Santiago (ES), Candiolo Cancer Institute (IT), University Medical Centre Mannheim (DE), Fondazione IRCCS Istituto Nazionale dei Tumori (IT), Servicio Gallego de Salud (ES), Instituto de Investigación de Enfermedades Raras (ES), Maastro Clinic (NL), Vall d'Hebron Institute of Oncology (ES), Icahn School of Medicine at Mount Sinai (US), KU Leuven (BE)
Fundación Cellex, Centres de Recerca de Catalunya, Cancer Research UK, National Institute for Health and Care Research, Department of Health and Social Care, University of Leicester, European Commission, Bundesministerium für Bildung und Forschung, Generalitat de Catalunya, Manchester Biomedical Research Centre, Instituto de Salud Carlos III, Agencia Estatal de Investigación, NIHR Leicester Biomedical Research Centre
Openalex Percentile: Top 23%
Cancer survivorship and care
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