Protective effect of the aqueous extract of Tabernaemontana stapfiana (Apocynaceae) stem bark against monosodium glutamate-induced neurotoxicity in Swiss albino mice

Background: Monosodium glutamate (MSG), a common food additive, is known to enhance taste and flavour. However, increasing evidence suggests that elevated MSG intake is linked to neuronal pathologies and death. Methods: ). Behavioural parameters such as Y-maze, elevated plus maze, open field and wire suspension tests were evaluated on days 8, 9, and 10 using various tests. After 10 days, biomarkers of oxidative stress and acetylcholinesterase activity were evaluated in the brain. Results: MSG induced oxidative stress, poor muscle coordination, and spatial short-term memory impairment in mice. The Conclusion: Results suggest that