Mechanism of MutLβ-dependent DNA expansions
and physically interacts with MutLγ, MutSβ, and PCNA. In addition, MutLβ suppresses inhibition of DNA expansion by MutSα. An MLH1-F80V substitution in MutLβ causes a defect in the ability of the protein to promote MutSβ- and MutLγ-dependent DNA expansions. Taken together, our findings support a model in which MutLβ is involved in DNA expansions by acting in a MutSβ- and MutLγ-dependent mechanism that includes incision of loop-containing DNAs in the loop-lacking strand.
Authors
- Farid F. Kadyrov (ORCID: https://orcid.org/0000-0002-7809-2991)
- Lyudmila Y. Kadyrova (ORCID: https://orcid.org/0000-0002-8135-9095)
- Karen Usdin (ORCID: https://orcid.org/0000-0003-3295-0740)
- BRUCE HAYWARD
- Farid A. Kadyrov
Institutions
- Southern Illinois University School of Medicine (US)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1073/pnas.2601397123
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of General Medical Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development