Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis
transcription via Notch1b signaling to prevent excessive shrinkage. Together, these findings reveal that mechanotransduction can dictate organ formation through dynamic cell volume regulation, uncovering a fundamental principle of morphogenesis.
Authors
- Igor Kondrychyn (ORCID: https://orcid.org/0000-0002-2268-7291)
- Thomas Juan (ORCID: https://orcid.org/0000-0002-9654-3717)
- Julien Vermot
- Moe Fukumoto (ORCID: https://orcid.org/0000-0001-8081-1353)
- Konstantinos Kalyviotis (ORCID: https://orcid.org/0000-0002-7640-8905)
- Periklis Pantazis (ORCID: https://orcid.org/0000-0002-8367-9332)
- Li‐Kun Phng (ORCID: https://orcid.org/0000-0001-8523-9958)
- Christina Vagena-Pantoula (ORCID: https://orcid.org/0000-0002-3591-2267)
- Antoine Sanchez
- Didier Y. R. Stainier (ORCID: https://orcid.org/0000-0002-0382-0026)
- Shuyi Feng (ORCID: https://orcid.org/0000-0002-7815-9682)
Institutions
- Uppsala University (SE)
- King's College London (GB)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- The Francis Crick Institute (GB)
- Max Planck Institute for Heart and Lung Research (DE)
- National Cerebral and Cardiovascular Center (JP)
- RIKEN Center for Biosystems Dynamics Research (JP)
- German Centre for Cardiovascular Research (DE)
- Cardio-Pulmonary Institute (DE)
- Imperial College London (GB)
Publication Details
- Journal
- Science Advances
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1126/sciadv.aea7025
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome
- Naito Foundation
- Imperial College London
- European Commission
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- Japan Society for the Promotion of Science
- RIKEN
- H2020 European Research Council