Cannabis Use and the Risk of Incident Venous Thromboembolism Among People With HIV: A Longitudinal Cohort Study in the United States
ABSTRACT: People with HIV (PWH) are at an increased risk of venous thromboembolism (VTE), and cannabis use is common in this population. However, evidence of cannabis impact on VTE risk has been conflicting and not well evaluated in PWH. Using data from five Centers for AIDS Research Network of Integrated Clinical Systems sites (2009-2020), we assessed the association between cannabis use and VTE risk. Among 13,646 PWH, 30% reported current cannabis use. In adjusted Cox models, neither former (adjusted hazard ratio [aHR] 0.78, 95% confidence interval (CI) 0.57-1.07) nor current (aHR 0.74, 95% CI 0.51-1.06) cannabis use showed a significant increase in VTE incidence compared with never use. Additionally, no dose-dependent relationship was observed between cannabis use frequency and VTE. Among PWH, cannabis use does not appear to be associated with an elevated risk of VTE. Further research is needed to elucidate the relationship between cannabis and VTE risk in this population.
Authors
- Sonya L. Heath (ORCID: https://orcid.org/0000-0002-3826-0954)
- Engi F. Attia (ORCID: https://orcid.org/0000-0002-5044-9602)
- J J
- R J Fredericksen
- Lydia N. Drumright (ORCID: https://orcid.org/0000-0002-3361-8080)
- Geetanjali Chander (ORCID: https://orcid.org/0000-0002-2216-6330)
- Kristina Crothers (ORCID: https://orcid.org/0000-0001-9702-0371)
- Andrew W. Hahn (ORCID: https://orcid.org/0000-0002-9552-1700)
- Michael S. Saag (ORCID: https://orcid.org/0000-0002-8866-1043)
- Sherif Eltonsy (ORCID: https://orcid.org/0000-0002-0520-5406)
- Stephanie A. Ruderman (ORCID: https://orcid.org/0000-0002-0058-5729)
- Mari M. Kitahata (ORCID: https://orcid.org/0000-0002-5410-7175)
- Bridget M. Whitney (ORCID: https://orcid.org/0000-0002-3738-5704)
- H M Crane
- J A C Delaney
- Jeanne Keruly
- L. Sarah Mixson
- Peter Hunt
- Edward Cachay
- Sonia Napravnik
- Greer Burkholder
- Robin M. Nance
- Laura Bamford
- Lara Haidar
- Richard D. Moore
Institutions
- University of North Carolina at Chapel Hill (US)
- Johns Hopkins University (US)
- University of California, San Francisco (US)
- University of Washington (US)
- Johns Hopkins Medicine (US)
- Research Manitoba (CA)
- University of Alabama at Birmingham (US)
- University of California San Diego (US)
- Neurobehavioral Systems (US)
- Mayo Clinic in Arizona (US)
- University of Manitoba (CA)
Publication Details
- Journal
- Journal of the Association of Nurses in AIDS Care
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1097/jnc.0000000000000641
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00