Bilayer tri-dermal-network hydrogel for sequential delivery of PD-168077 in multimodal diabetic wound regeneration
, PCHMA markedly accelerated wound closure in db/db mice, while simultaneously improving angiogenesis and extracellular matrix remodeling. This integrated platform, combining a precisely-screened drug with a translational, bioactive delivery system, offers a promising, multimodal strategy for DCW management.
Authors
- Ming-Yuan Jin
- Rui Zhang (ORCID: https://orcid.org/0000-0003-0822-1513)
- Yong He (ORCID: https://orcid.org/0000-0002-9099-0831)
- Ting-Ting Jin
- Yan-Yan Hu
- Ji Wang
- Jing-Yu Li
- Li-Li Wang
- Yi Sun
- Su-Fan Wu
- Yi Zhou
Institutions
- Qinghai University (CN)
- Zhejiang Provincial People's Hospital (CN)
- Hangzhou Medical College (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Bioactive Materials
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1016/j.bioactmat.2026.04.021
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China