Plasma inflammatory markers and brain white matter microstructure in late middle-aged and older adults
). Thus, higher levels of peripheral pro-inflammatory markers are associated with white matter microstructure (higher FWF, ODI, and MD), supporting the view that these dMRI-based metrics are sensitive to inflammatory processes. Additionally, the sensitivity of dMRI-based measures to inflammation may differ by inflammatory marker types.
Authors
- Anja Soldan (ORCID: https://orcid.org/0000-0002-6193-0418)
- Elizabeth R. Paitel (ORCID: https://orcid.org/0000-0001-6507-0411)
- Corinne Pettigrew
- Nan‐kuei Chen (ORCID: https://orcid.org/0000-0001-6564-4219)
- Abhay Moghekar (ORCID: https://orcid.org/0000-0001-9464-1551)
- Kristian P. Doyle (ORCID: https://orcid.org/0000-0003-2788-7038)
- Jennifer B. Frye
- Siona Mishra
- Lee Ryan
- Sara Grace Ho
- Marilyn Albert
- Chidi Ugonna
Institutions
- University of Arizona (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-04-22
- DOI
- https://doi.org/10.64898/2026.04.20.26351124
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00