Synthesis and Characterization of Regenerated Cellulose Coated with a Silk Fibroin/Hydroxyapatite Scaffold for Enhanced Adhesion and Proliferation of Preosteoblast Cells

/g, while the compressive strength was increased from 8.28 ± 0.14 MPa to 20.46 ± 0.62 MPa. The scaffolds exhibited high viability of MC3T3-E1 preosteoblast cells (>85%), indicating no adverse cytotoxicity to the cells. The in vitro cell test also established that the scaffold supports bone cell proliferation (from 40% to 77.34%) in 7 days and protein adsorption. This was further confirmed by live/dead staining, cell adhesion, and morphology tests. These findings highlight the potential of regenerated cellulose-based scaffolds, functionalized with an SF/HA coating, for bone tissue engineering.