Dual CD73/A2AR blockade modulates the neurotoxic astrocyte phenotype without disrupting core inflammatory signaling
Introduction: R axis to constrain maladaptive inflammatory signaling. Methods: R spatial proximity, cytokine release, and astrocyte-mediated neurotoxicity. Results: homeostasis and improving neuronal viability. Discussion: R axis as a promising therapeutic target for limiting chronic astrocyte-driven neurotoxicity.
Authors
- Lucille Adam
- Arnaud Mansart (ORCID: https://orcid.org/0000-0003-1442-8924)
- Nadežda Nedeljković (ORCID: https://orcid.org/0000-0003-3046-0983)
- Stéphane Vinit (ORCID: https://orcid.org/0000-0001-7013-1741)
- Katarina Mihajlović (ORCID: https://orcid.org/0000-0002-9385-5002)
- Ivana Stevanović (ORCID: https://orcid.org/0000-0002-4588-3447)
- Milorad Dragić (ORCID: https://orcid.org/0000-0003-4855-6131)
- Marêva Bleuzé
- Teodora Martić
- Marija Adzic Bukvic
Institutions
- Military Medical Academy (RS)
- Inserm (FR)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Université Paris-Saclay (FR)
- University of Belgrade (RS)
- Centre de Recherche sur l'Inflammation (FR)
- Institute of Economic Sciences (RS)
- Military Medical Academy (EG)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-04-22
- DOI
- https://doi.org/10.3389/fphar.2026.1778355
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00