Exploring bone formation mechanism and pattern during RANKL inhibition in a fibrous dysplasia mouse model
(FD) mice receiving an anti-mouse RANKL antibody. We show that, although the treatment reduces the expression of osteogenic genes, osteoblastic cells continue to produce bone matrix within FD lesions. However, bone formation does not occur in a diffuse or stochastic manner but follows an ordered spatial pattern that is restricted to the surfaces of the lesional bone. These results suggest that during RANKL inhibition the amount of intra-lesional bone trabecular surfaces is critical to the process of cell differentiation and to the skeletal improvement that FD patients may achieve during the treatment.
Authors
- Alessia Ciarrocchi (ORCID: https://orcid.org/0000-0002-5541-2075)
- Benedetta Donati (ORCID: https://orcid.org/0000-0002-9163-8194)
- Alessandro Corsi (ORCID: https://orcid.org/0000-0001-6896-4509)
- Biagio Palmisano (ORCID: https://orcid.org/0000-0002-1287-5256)
- Mara Riminucci (ORCID: https://orcid.org/0000-0002-8643-9211)
- Iolanda Coletta
- Mary Anna Venneri (ORCID: https://orcid.org/0000-0002-0687-8135)
- Debora Salerno (ORCID: https://orcid.org/0000-0003-0504-1904)
- Domenico Raimondo (ORCID: https://orcid.org/0000-0002-1780-7295)
- Giorgia Farinacci (ORCID: https://orcid.org/0000-0003-0122-0155)
- Samantha Donsante (ORCID: https://orcid.org/0000-0001-6970-758X)
- Emanuela Spica
- Tiziana Borsello (ORCID: https://orcid.org/0000-0002-9729-7642)
- Chiara Tavanti
- Samuele Di Cristofano (ORCID: https://orcid.org/0000-0002-9618-9391)
- Marta Serafini
Institutions
- University of Milan (IT)
- Mario Negri Institute for Pharmacological Research (IT)
- Istituto Neurologico Mediterraneo (IT)
- Azienda Sanitaria Unità Locale di Reggio Emilia (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto Pasteur (IT)
- University of Milano-Bicocca (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Communications Biology
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1038/s42003-026-10097-z
- Primary Topic
- Bone Tumor Diagnosis and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00