Rare protein-disrupting variants in <i>NPY5R, DLGAP1</i> and <i>MAPK8IP3</i> segregate with OCD in two multiplex pedigrees
which we had previously identified in a large Tourette Syndrome pedigree. Our analysis suggests that both energy homeostasis and downstream signalling from the post-synaptic density may both be important avenues for future research.
Authors
- Aiden Corvin (ORCID: https://orcid.org/0000-0001-6717-4089)
- Cathal Ormond (ORCID: https://orcid.org/0000-0002-5717-0508)
- Elizabeth A. Heron (ORCID: https://orcid.org/0000-0003-2219-4005)
- Denise A. Chavira (ORCID: https://orcid.org/0000-0002-6403-2509)
- Carol A. Mathews (ORCID: https://orcid.org/0000-0003-2208-7058)
- Yi-Chieh Chang
- Kyle Williams
- Mathieu Cap
- Jon E Grant
Institutions
- University of California, Los Angeles (US)
- Trinity College Dublin (IE)
- University of Florida (US)
- University of Chicago (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-04-22
- DOI
- https://doi.org/10.64898/2026.04.21.26350600
- Primary Topic
- Obsessive-Compulsive Spectrum Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00