Notch Signalling Pathway in the Pathogenesis of Periodontitis: Research Progress

AIMS: This review examines the pivotal role of the Notch signalling pathway in the pathogenesis of periodontitis. We focus on its impact on the host inflammatory response, immune regulation, and alveolar bone homeostasis. By delineating how periodontal pathogens activate this pathway to exacerbate tissue damage, we also explore its potential as a therapeutic target. METHODS: This article synthesises and critically examines recent advances in research on the Notch signalling pathway in the context of periodontitis. By comprehensively reviewing and evaluating current literature, the methods include analysing mechanistic insights, experimental findings, and clinical evidence related to Notch signalling in periodontal pathogenesis. RESULTS: The review highlights that the Notch signalling pathway significantly influences the pathogenesis of periodontitis, impacting key disease processes such as inflammation, immune response, and tissue regeneration. It summarises evidence demonstrating the pathway's involvement in disease progression and its potential as a therapeutic target, while also identifying existing challenges and gaps in current knowledge. CONCLUSION: This review underscores the critical role of Notch signalling in periodontitis and contributes to a deeper understanding of the molecular mechanisms driving the disease. It encourages the development of novel therapeutic strategies and emphasises the need for further research to address unresolved questions and translate findings into clinical applications.