CD39/CD73-mediated immunosuppression and tumor aggressiveness in bladder cancer
T-cells were significantly associated with higher pathological grade and distinguished high-grade tumors with moderate accuracy (AUC > 0.70). This study demonstrates that BCa is characterized by extensive AP-linked immunosuppression, and that specific ectonucleotidase-expressing circulating T-cell subsets may serve as non-invasive biomarkers for assessing tumor infiltration and grade.
Authors
- Célia Gomes (ORCID: https://orcid.org/0000-0002-7497-4129)
- S Silva
- Artur Augusto Paiva (ORCID: https://orcid.org/0000-0002-6562-5859)
- B. Parada (ORCID: https://orcid.org/0000-0002-9911-4926)
- Vítor Sousa (ORCID: https://orcid.org/0000-0003-3219-1078)
- Paula Laranjeira (ORCID: https://orcid.org/0000-0002-1136-6118)
- Margarida Pereira
- Guilherme Fontinha
- Isabel Silva
- Frederico Furriel
Institutions
- Instituto Politécnico de Leiria (PT)
- Hospitais da Universidade de Coimbra (PT)
- Polytechnic Institute of Coimbra (PT)
- Administração Regional de Saúde de Lisboa e Vale do Tejo (PT)
- University of Coimbra (PT)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1007/s00262-026-04400-4
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidade de Coimbra
- Liga Portuguesa Contra o Cancro