A CRISPR-Cas9 screen identifies LAPTM4A (lysosomal protein transmembrane 4 alpha) as a key host barrier against PRRSV infection
: 50% tissue culture infective dose; TFEB: transcription factor EB; Ub: ubiquitin; ULK1: unc-51 like autophagy activating kinase 1; WT: wild type.
Authors
- Pengwei Zhao (ORCID: https://orcid.org/0000-0002-2526-5705)
- Chunhe Guo (ORCID: https://orcid.org/0000-0002-7859-1985)
- Jiecong Yan
- Zhan He (ORCID: https://orcid.org/0009-0002-9778-8158)
- Nianqi Zhang
- Fangfang Li
- Min Liu
Institutions
- South China Agricultural University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Autophagy
- Published
- 2026-04-23
- DOI
- https://doi.org/10.1080/15548627.2026.2664607
- Primary Topic
- Animal Virus Infections Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China