Novel 1-Phenyl-2,3-dihydroquinazolin-4(1H)-one Derivatives as Na <sub>v</sub> 1.8 Voltage-Gated Sodium Channels Inhibitors
This highlight outlines the development of novel substituted 1-phenyl-2,3-dihydroquinazolin-4(1H)-one derivatives as potential inhibitor candidates for Nav 1.8 voltage-gated sodium channels (Nav 1.8), which is upregulated or activated to transmit nociceptive signaling in a range of pain-related disorders. The invention includes details on preparation methods, biological activity assays, and pharmaceutical compositions.
Authors
- Steven H. Liang (ORCID: https://orcid.org/0000-0003-1413-6315)
- Ruihu Song
Institutions
- Georgia Institute of Technology (US)
- Emory University (US)
- The Wallace H. Coulter Department of Biomedical Engineering (US)
Publication Details
- Journal
- ACS Medicinal Chemistry Letters
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1021/acsmedchemlett.6c00189
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 0.00