Quantitative Spatial Profiling of Antibody Delivery and Target Engagement Using Optically Labeled Antibodies
We established a multiplex imaging platform that enables single-cell analysis of therapeutic antibody delivery and pharmacodynamics in human formalin-fixed, paraffin-embedded tissues.
Authors
- Georgii Vasiukov (ORCID: https://orcid.org/0000-0003-4768-5388)
- Candace J. Grisham (ORCID: https://orcid.org/0000-0002-5043-534X)
- Mabrooka Kazi
- Shravan Gowrishankar
- Eben L. Rosenthal
- Hidenori Tanaka
Institutions
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Journal of Nuclear Medicine
- Published
- 2026-04-22
- DOI
- https://doi.org/10.2967/jnumed.125.271992
- Primary Topic
- Advanced Fluorescence Microscopy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00