Novel Knotted Solenoid fold with order-shifted coil arrangement leads to nontrivial 3 <sub>1</sub> topology
knotted state through a slipknot intermediate. It then interacts with another chain via its hydrophobic surface, promoting second chain folding and dimerization. The identification of novel knotted proteins within a previously considered unknotted fold provides an opportunity to investigate the evolutionary pressures and functional implications of knotting in shaping protein architecture.
Authors
- Anna Kluza (ORCID: https://orcid.org/0000-0002-0757-5179)
- Joanna I. Sułkowska (ORCID: https://orcid.org/0000-0003-2452-0724)
- Sophie Jackson (ORCID: https://orcid.org/0000-0002-7470-9800)
- Szymon Niewieczerzał (ORCID: https://orcid.org/0000-0002-7563-7212)
- Agata P. Perlinska (ORCID: https://orcid.org/0000-0003-2806-1190)
- Mariusz Możajew (ORCID: https://orcid.org/0000-0001-6157-2860)
- Maciej Sikora (ORCID: https://orcid.org/0009-0003-0289-276X)
- Beata Wielgus‐Kutrowska (ORCID: https://orcid.org/0000-0002-5049-864X)
- Fernando Bruno da Silva (ORCID: https://orcid.org/0000-0002-0285-8700)
- Maciej Łukaszewicz (ORCID: https://orcid.org/0000-0002-2511-7091)
- Karolina Stachurska-Korzeniowska
- Julia A. Sikorska (ORCID: https://orcid.org/0000-0002-4117-9225)
Institutions
- Institute of Experimental Physics of the Slovak Academy of Sciences (SK)
- Regional Centre of Advanced Technologies and Materials (CZ)
- Universitas Islam Syekh Yusuf (ID)
- University of Warsaw (PL)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1073/pnas.2525920123
- Primary Topic
- Supramolecular Chemistry and Complexes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Narodowe Centrum Nauki