Transposable elements are driving rapid adaptation of Enterococcus faecium
. Together, these results show that a recent ISL3 expansion is driving rapid evolution in healthcare-associated E. faecium, with consequences for its metabolic fitness that may help explain its increasing clinical burden. Several other pathogens also show elevated IS loads in our survey, which suggests that IS expansion-mediated evolution might be more broadly relevant.
Authors
- Aaron A. Behr (ORCID: https://orcid.org/0000-0001-6660-9546)
- G. Rodriguez-Nava
- Erin F. Brooks (ORCID: https://orcid.org/0000-0002-5834-0679)
- Marco Molari (ORCID: https://orcid.org/0000-0001-8838-4093)
- Matthew P. Grieshop (ORCID: https://orcid.org/0000-0002-0075-8597)
- Sierra Bowden (ORCID: https://orcid.org/0000-0002-6862-7913)
- Jordan D. Lin
- Ami Siddharth Bhatt (ORCID: https://orcid.org/0000-0001-8099-2975)
- Niaz Banaei (ORCID: https://orcid.org/0000-0001-8501-3000)
- Boryana Doyle (ORCID: https://orcid.org/0000-0002-3209-5708)
- Gabriella Z. M. Reynolds (ORCID: https://orcid.org/0000-0002-8433-4264)
- Jorge L. Salinas
- Ashley A. Moore (ORCID: https://orcid.org/0009-0002-8459-7264)
Institutions
- SIB Swiss Institute of Bioinformatics (CH)
- University of Basel (CH)
- Stanford Health Care (US)
- Stanford Blood Center (US)
- Stanford Medicine (US)
- Case Western Reserve University (US)
- Stanford University (US)
Publication Details
- Journal
- Nature
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1038/s41586-026-10373-2
- Citations
- 2
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 40.53