Plasma expression of long non-coding RNA GAS5 and its prognostic significance in newly diagnosed multiple myeloma

Introduction: lncRNA in plasma samples of MM patients and to evaluate its clinical and prognostic significance. Methods and material: gene as endogenous control and by using the comparative ddCt method with control samples as a calibrator. Results: expression and advanced age were associated with shorter time to progression, while higher R2-ISS score, advanced age and occurrence of relapse/progression of disease were independent prognostic factors for survival in our group of patients. Conclusion: as a robust biomarker in MM, future studies should focus on larger patient cohorts to validate its expression within the bone marrow niche and its specific association with high-risk 'double-hit' cytogenetic aberrations and glucocorticoid resistance.