Modifiable PEDOT:PSS-based flexible diagnostic and therapeutic dressings for personalized wound management

> 0.99), and robust reproducibility. In vivo therapeutic efficacy, rigorously assessed using circular and square wound models in Sprague-Dawley rats, reveals that FDTD-mediated electro-optical synergistic therapy achieves greater than 98% wound closure within 8 days, significantly outperforming the control group (<65%) and other reported physical therapies (≤90%). Mechanistically, accelerated regeneration is attributed to improved cellular proliferation, collagen organization, and neovascularization facilitated by electro-optical synergistic treatment. Furthermore, the integration of wireless power transfer and Bluetooth modules enables real-time data acquisition and remote therapeutic modulation, positioning FDTD as a promising platform for transformative wound management.

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Publication Details

Journal
Microsystems & Nanoengineering
Published
2026-04-23
DOI
https://doi.org/10.1038/s41378-026-01200-9
Primary Topic
Wound Healing and Treatments
Type
article
Field-Weighted Citation Impact
0.00

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article

Modifiable PEDOT:PSS-based flexible diagnostic and therapeutic dressings for personalized wound management

Chenzheng Zhou, Siyuan Cai, Taisong Pan, Xingyi Gan et al.
Microsystems & Nanoengineering
Wound Healing and Treatments
article

Modifiable PEDOT:PSS-based flexible diagnostic and therapeutic dressings for personalized wound management

Chenzheng Zhou, Siyuan Cai, Taisong Pan, Xingyi Gan, Guang Yao, Yuan Lin, Binbin Jiang, Xuhan Ren, Zongkai Yan, Zhenlong Huang, Jia Zhu, Leyan Wang, Yuxin Gan, Min Gao
article en

Abstract

> 0.99), and robust reproducibility. In vivo therapeutic efficacy, rigorously assessed using circular and square wound models in Sprague-Dawley rats, reveals that FDTD-mediated electro-optical synergistic therapy achieves greater than 98% wound closure within 8 days, significantly outperforming the control group (<65%) and other reported physical therapies (≤90%). Mechanistically, accelerated regeneration is attributed to improved cellular proliferation, collagen organization, and neovascularization facilitated by electro-optical synergistic treatment. Furthermore, the integration of wireless power transfer and Bluetooth modules enables real-time data acquisition and remote therapeutic modulation, positioning FDTD as a promising platform for transformative wound management.

Microsystems & NanoengineeringVol. 12(1)
University of Electronic Science and Technology of China (CN), Army Medical University (CN), Xizang Minzu University (CN), Xinqiao Hospital (CN), National Engineering Research Center of Electromagnetic Radiation Control Materials (CN), Institute for Advanced Study (DE)
National Natural Science Foundation of China
Openalex Percentile: Top 18%
Wound Healing and Treatments
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