Modifiable PEDOT:PSS-based flexible diagnostic and therapeutic dressings for personalized wound management
> 0.99), and robust reproducibility. In vivo therapeutic efficacy, rigorously assessed using circular and square wound models in Sprague-Dawley rats, reveals that FDTD-mediated electro-optical synergistic therapy achieves greater than 98% wound closure within 8 days, significantly outperforming the control group (<65%) and other reported physical therapies (≤90%). Mechanistically, accelerated regeneration is attributed to improved cellular proliferation, collagen organization, and neovascularization facilitated by electro-optical synergistic treatment. Furthermore, the integration of wireless power transfer and Bluetooth modules enables real-time data acquisition and remote therapeutic modulation, positioning FDTD as a promising platform for transformative wound management.
Authors
- Chenzheng Zhou (ORCID: https://orcid.org/0000-0002-9767-9448)
- Siyuan Cai
- Taisong Pan (ORCID: https://orcid.org/0000-0003-1576-3409)
- Xingyi Gan (ORCID: https://orcid.org/0009-0000-4514-2473)
- Guang Yao (ORCID: https://orcid.org/0000-0002-6662-2422)
- Yuan Lin (ORCID: https://orcid.org/0000-0002-9879-4341)
- Binbin Jiang
- Xuhan Ren
- Zongkai Yan
- Zhenlong Huang
- Jia Zhu
- Leyan Wang
- Yuxin Gan
- Min Gao
Institutions
- University of Electronic Science and Technology of China (CN)
- Army Medical University (CN)
- Xizang Minzu University (CN)
- Xinqiao Hospital (CN)
- National Engineering Research Center of Electromagnetic Radiation Control Materials (CN)
- Institute for Advanced Study (DE)
Publication Details
- Journal
- Microsystems & Nanoengineering
- Published
- 2026-04-23
- DOI
- https://doi.org/10.1038/s41378-026-01200-9
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China