SENP3 regulates DNA damage repair by downregulating RAP80 SUMOylation

depletion impairs HR repair and increases cellular sensitivity to irradiation and chemotherapy drugs. Collectively, our findings identify SENP3 as a key regulator of DNA repair through its dynamic control of RAP80-BRCA1 complex formation and DNA damage repair processes.

Authors

Jianfeng Fu
Ruidan Xu
Xiaofeng Zheng
Min Wei

Institutions

Peking University (CN)

Publication Details

Journal: Acta Biochimica et Biophysica Sinica
Published: 2026-04-23
DOI: https://doi.org/10.3724/abbs.2026075
Primary Topic: DNA Repair Mechanisms
Type: article
Field-Weighted Citation Impact: 0.00

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article

SENP3 regulates DNA damage repair by downregulating RAP80 SUMOylation

Jianfeng Fu, Ruidan Xu, Xiaofeng Zheng, Min Wei

Apr 23, 2026

Acta Biochimica et Biophysica Sinica

DNA Repair Mechanisms

article

SENP3 regulates DNA damage repair by downregulating RAP80 SUMOylation

Jianfeng Fu, Ruidan Xu, Xiaofeng Zheng, Min Wei

April 23, 2026article en

Abstract

Acta Biochimica et Biophysica Sinica

Peking University (CN)

Openalex Percentile: Top 20%

DNA Repair Mechanisms

DOI Open Access PDF OpenAlex

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SENP3 regulates DNA damage repair by downregulating RAP80 SUMOylation — Jianfeng Fu, Ruidan Xu, et al. · Acta Biochimica et Biophysica Sinica (2026) | TGRS Research Map | TGRS