Giant vulvar verruciform xanthoma in a child: a rare case report and literature review

Verruciform xanthoma (VX) is a rare benign mucocutaneous proliferative lesion that primarily affects the oral mucosa and, in rare cases, the genital mucosa and skin. Due to its uncommon occurrence and varied, non-specific clinical manifestations, the condition is prone to misdiagnosis and missed diagnosis. This report introduces an even rarer case of pediatric vulvar VX, providing a detailed interpretation and analysis of the ultrasonographic features of this condition. Furthermore, in conjunction with previous literature, this report summarizes and analyzes the currently reported vulvar VX cases, aiming to obtain effective diagnostic and therapeutic information, enhance preoperative diagnostic accuracy, and improve patient prognosis.

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Publication Details

Journal
Frontiers in Medicine
Published
2026-04-22
DOI
https://doi.org/10.3389/fmed.2026.1774843
Primary Topic
Genetic and rare skin diseases.
Type
article
Field-Weighted Citation Impact
0.00
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article

Giant vulvar verruciform xanthoma in a child: a rare case report and literature review

Bin Dong, Yan Xia, Hongyan Jiang, Hongsheng Xia et al.
Frontiers in Medicine
Genetic and rare skin diseases.
article

Giant vulvar verruciform xanthoma in a child: a rare case report and literature review

Bin Dong, Yan Xia, Hongyan Jiang, Hongsheng Xia, Ying Liu
article en

Abstract

Verruciform xanthoma (VX) is a rare benign mucocutaneous proliferative lesion that primarily affects the oral mucosa and, in rare cases, the genital mucosa and skin. Due to its uncommon occurrence and varied, non-specific clinical manifestations, the condition is prone to misdiagnosis and missed diagnosis. This report introduces an even rarer case of pediatric vulvar VX, providing a detailed interpretation and analysis of the ultrasonographic features of this condition. Furthermore, in conjunction with previous literature, this report summarizes and analyzes the currently reported vulvar VX cases, aiming to obtain effective diagnostic and therapeutic information, enhance preoperative diagnostic accuracy, and improve patient prognosis.

Frontiers in MedicineVol. 13
Zhejiang Chinese Medical University (CN), Third People's Hospital of Hangzhou (CN), The Third Affiliated Hospital of Zhejiang Chinese Medical University (CN), Hangzhou Medical College (CN)
Openalex Percentile: Top 22%
Genetic and rare skin diseases.
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