Evolutionary history of Jamestown Canyon virus reveals complex multi-vector ecology
/year, which is more similar to slow-moving tick-borne viruses than to other mosquito-borne viruses. We found that univoltine Aedes mosquitoes were likely to maintain the virus across years through overwintering in eggs, accounting for its slow evolution and dispersal, while multivoltine mosquitoes contributed to periodic bursts of spatial diffusion and amplification within seasons. We demonstrate the utility of dense sequencing and phylodynamics to disentangle complex transmission cycles, offering a framework for rapidly advancing our evolutionary and ecological knowledge of understudied viruses.
Authors
- Angela Bransfield
- Keith J. Price (ORCID: https://orcid.org/0000-0002-5328-6327)
- Fabiana Gámbaro (ORCID: https://orcid.org/0000-0001-7760-2112)
- Nathan D. Grubaugh (ORCID: https://orcid.org/0000-0003-2031-1933)
- Colin J. Carlson (ORCID: https://orcid.org/0000-0001-6960-8434)
- Verity Hill (ORCID: https://orcid.org/0000-0002-3509-8146)
- Nicole M. Feriancek (ORCID: https://orcid.org/0000-0003-1832-812X)
- Joseph G. Maffei (ORCID: https://orcid.org/0000-0001-5772-5561)
- John J. Shepard (ORCID: https://orcid.org/0000-0001-7342-5147)
- Stephen M. Rich (ORCID: https://orcid.org/0000-0001-7175-6380)
- Marc A. Suchard (ORCID: https://orcid.org/0000-0001-9818-479X)
- Tanya A. Petruff
- Alan P. Dupuis (ORCID: https://orcid.org/0000-0003-0703-9250)
- Mallery I. Breban (ORCID: https://orcid.org/0000-0002-8976-9988)
- Theodore G. Andreadis (ORCID: https://orcid.org/0000-0003-4924-0585)
- Michael J. Misencik
- Madeline L. Metzger (ORCID: https://orcid.org/0000-0002-8755-350X)
- Philip M. Armstrong (ORCID: https://orcid.org/0000-0002-7261-9748)
- Alexander T. Ciota (ORCID: https://orcid.org/0000-0001-6589-4728)
- Ellie Bourgikos
- Chantal B.F. Vogels
- Rafael Lopes
- Kiet A. Ngo
- John F. Anderson
- Gabrielle Sakolsky
- Simon Dellicour
- Guang Xu
- Philippe Lemey
- Guy Baele
Institutions
- New York State Department of Health (US)
- Université Libre de Bruxelles (BE)
- Pennsylvania Department of Environmental Protection (US)
- Wadsworth Center (US)
- University of California, Los Angeles (US)
- Amherst College (US)
- Rega Institute for Medical Research (BE)
- University of Massachusetts Amherst (US)
- Connecticut Agricultural Experiment Station (US)
- Yale University (US)
- Yale New Haven Health System (US)
- Consolidated Mosquito Abatement District (US)
Publication Details
- Journal
- Current Biology
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1016/j.cub.2026.03.076
- Primary Topic
- Plant Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- European Commission
- Fonds De La Recherche Scientifique - FNRS
- Fonds Wetenschappelijk Onderzoek
- National Institutes of Health
- National Institute of General Medical Sciences
- National Institute of Allergy and Infectious Diseases