Electroenzymatic C1 Fixation to Glycine via Dithiothreitol Regeneration on Functionalized 1T′-MoS <sub>2</sub>
catalyst further enhances its performance through precise interfacial microenvironment engineering. Critically, this electrochemical regeneration system is fully biocompatible, enabling its seamless integration with a downstream chemoenzymatic cascade for glycine synthesis. The mild operating conditions preserve enzyme integrity, ensuring sustained high catalytic activity and achieving a 2-fold enhancement in glycine production up to 12.2 mM over 9 h. This work establishes a sustainable platform for C1 valorization by synergistically coupling electrocatalytic and chemoenzymatic processes, providing a generalizable platform for renewable energy-driven biomanufacturing.
Authors
- Chengyi Hu (ORCID: https://orcid.org/0000-0002-7962-2034)
- An‐Ping Zeng (ORCID: https://orcid.org/0000-0001-9768-7096)
- Nanfeng Zheng (ORCID: https://orcid.org/0000-0001-9879-4790)
- Jianming Liu (ORCID: https://orcid.org/0000-0001-6527-6049)
- Zixiao Zhao
- Meiquan Huang
- Junxiang Chen
- Qianqin Wang
- Shengjun Liu
- Yin Gao
Institutions
- Xiamen University (CN)
- Chinese Academy of Sciences (CN)
- Westlake University (CN)
- Fujian Institute of Research on the Structure of Matter (CN)
- Tan Kah Kee Innovation Laboratory (CN)
- Collaborative Innovation Center of Chemistry for Energy Materials (CN)
- RE Hydrogen (United Kingdom) (GB)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1021/jacs.6c03530
- Primary Topic
- Metalloenzymes and iron-sulfur proteins
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- National Key Research and Development Program of China