Chirality-Driven Immune Checkpoint Modulation by Chiral Iridium(III) Nanoparticles
T cells to remodel the tumor microenvironment. This work pioneers the discovery of nanoscale metal-centered chirality in precisely targeting immune checkpoints and highlights the pivotal role of delta configurations in enhancing anticancer immune responses, paving the way for the future rational design of effective metal-based immunotherapies.
Authors
- Jiajia Ma (ORCID: https://orcid.org/0000-0002-4339-0462)
- Yunfei Deng (ORCID: https://orcid.org/0000-0002-1327-724X)
- Wenfeng Jiang
- Yue Qin (ORCID: https://orcid.org/0000-0003-4277-3602)
- Shiqi Gao
- Yunlong Mao
- Ze Wen
- Shengjin Liu
- Xiaoyong Wang (ORCID: https://orcid.org/0000-0002-8338-9773)
- Lu Zhu
- Maokai Yu
- Jingyi Zhang
- Tian Tian (ORCID: https://orcid.org/0009-0004-5712-6162)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Shanghai Jiao Tong University (CN)
- Novel (United States) (US)
- State Key Laboratory of Chemical Engineering (CN)
- Institute of New Materials (CN)
- Wuxi Institute of Technology (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1021/jacs.6c00020
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundamental Research Funds for the Central Universities