Cyclic mechanical stretch suppresses intrinsic apoptosis in high metastatic melanoma
models further demonstrated that prior mechanical conditioning enhanced survival and metastatic behavior in high metastatic melanoma. Together, these findings reveal that cyclic mechanical stress promotes apoptosis resistance in a metastatic potential-dependent manner and highlight the importance of considering tissue mechanics in understanding melanoma progression and therapeutic response.
Authors
- T Lee
- Hyun‐Jong Cho (ORCID: https://orcid.org/0000-0002-5070-9371)
- Minseok Kim (ORCID: https://orcid.org/0000-0002-7821-4485)
- Geonwoo Kim (ORCID: https://orcid.org/0000-0002-6274-3649)
- Junmin Lee (ORCID: https://orcid.org/0000-0002-4414-7130)
- Giheon Ha
- Wonjun Jang
- Soojin Park
- Yu Shrike Zhang
- Geonho Lee
- Han-Jun Kim
Institutions
- Pohang University of Science and Technology (KR)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Kangwon National University (KR)
- Korea University (KR)
- Sejong University (KR)
- Korea University (JP)
Publication Details
- Journal
- Materials Today Bio
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1016/j.mtbio.2026.103132
- Primary Topic
- Cellular Mechanics and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation of Korea