Systematic evaluation of TCGA tumor microbiota reveals context-dependent reliability
not only validated its predicted gene expression changes in oral cancer cells but also revealed a significant promotion of cancer cell proliferation and migration. Our study provides a rigorous framework for interpreting TCGA's tumor microbiome and highlights that these data require careful, multi-layered validation to yield robust biological insights. IMPORTANCE: , and proved in the lab that it makes oral cancer cells grow faster and spread. Our publicly available Multi-Omics and Microbiome Associations in Cancer 2 (MOMAC2) web portal now allows scientists to use these reliability-graded findings to accelerate robust cancer microbiome research.
Authors
- Shimin Shuai (ORCID: https://orcid.org/0000-0002-9527-8018)
- Chenchen Ma (ORCID: https://orcid.org/0000-0003-0449-1911)
- Jiaxuan Li (ORCID: https://orcid.org/0000-0002-1782-5784)
- Jiuxin Qu (ORCID: https://orcid.org/0000-0003-1061-2353)
- Changxing Su
- Jun Jiang (ORCID: https://orcid.org/0000-0002-1521-5421)
- Yi-Xiang Wang (ORCID: https://orcid.org/0000-0002-4021-4228)
- Jianliang Liao
- Guoquan Zhang
- Lanlan Cheng
Institutions
- Southern University of Science and Technology (CN)
- First People's Hospital of Foshan (CN)
- Institute of Human Genetics (PL)
- National Clinical Research (US)
- Shenzhen Third People’s Hospital (CN)
Publication Details
- Journal
- mSystems
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1128/msystems.00180-26
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China