Silk fibroin reinforced decellularized porcine pericardial patch with superior strength, biocompatibility, and non-toxicity as a regenerative replacement for cardiovascular applications

cytocompatibility and toxicological studies further confirmed that SFDPP is biocompatible and non-toxic, making it suitable for cardiovascular applications. Rat subcutaneous implantation has proven SFDPP to be associated with significantly reduced inflammation and mineralization compared to the commercially available SJM Biocor pericardial patch. Results from rat abdominal wall defect and pig aortic vascular defect models demonstrated that SFDPP patch promoted structural restoration by site-appropriate constructive remodelling in both the defects. All these evidences confirmed its efficacy as a potential patch for treating cardiovascular defects.