Focal white matter lesions drive grey matter inflammation and synapse loss
. Our findings reveal a form of regenerative plasticity coupling white matter integrity to grey matter function, which may underlie multiple neurodegenerative conditions, and highlight the potential of targeting myelin regeneration to prevent chronic neuroinflammation.
Authors
- Soyon Hong (ORCID: https://orcid.org/0000-0002-5744-4871)
- Eneritz Agirre (ORCID: https://orcid.org/0000-0002-5012-0305)
- Javier Rueda‐Carrasco (ORCID: https://orcid.org/0000-0002-9280-6612)
- Andrea López-López (ORCID: https://orcid.org/0000-0002-1692-9637)
- George G. Malliaras (ORCID: https://orcid.org/0000-0002-4582-8501)
- Yasmine Kamen (ORCID: https://orcid.org/0000-0003-1867-7397)
- Kimberley Anne Evans (ORCID: https://orcid.org/0000-0001-7037-8533)
- Bastien Hervé (ORCID: https://orcid.org/0000-0002-2610-8365)
- Tanja Mist Birgisdóttir
- Gonçalo Castelo‐Branco (ORCID: https://orcid.org/0000-0003-2247-9393)
- Ragnhildur Thóra Káradóttir (ORCID: https://orcid.org/0000-0001-9675-2722)
- Michael Perry (ORCID: https://orcid.org/0000-0001-9112-1227)
- Sabrina Ghosh (ORCID: https://orcid.org/0009-0003-0325-7346)
- Sindri Gíslason (ORCID: https://orcid.org/0000-0002-6325-672X)
- Helena Pivoňková (ORCID: https://orcid.org/0000-0003-2790-9778)
- Sebastian Timmler (ORCID: https://orcid.org/0000-0001-9258-2965)
- Balázs Varga (ORCID: https://orcid.org/0000-0002-4005-1203)
- Joseph J. Y. Wong
- Sabine Dietmann (ORCID: https://orcid.org/0000-0001-6672-8457)
- Katrin Volbracht (ORCID: https://orcid.org/0000-0002-6585-263X)
- Stavros Vagionitis (ORCID: https://orcid.org/0000-0002-9501-0695)
- Hélène Gautier (ORCID: https://orcid.org/0000-0002-3302-9470)
- Felix Hildebrand (ORCID: https://orcid.org/0009-0001-8279-0207)
- Mert Yucel (ORCID: https://orcid.org/0000-0002-9344-0616)
- Courtney Kremler
- Omar de Faria (ORCID: https://orcid.org/0000-0002-7919-9555)
- Leslie Rodríguez-Kirby
- Andrew T. Setley (ORCID: https://orcid.org/0009-0004-9746-3091)
- Christian A. Cepeda
Institutions
- University of Iceland (IS)
- Washington University in St. Louis (US)
- Wellcome/MRC Cambridge Stem Cell Institute (GB)
- University of Cambridge (GB)
- Karolinska Institutet (SE)
- Bridge University (SS)
- Center for Research in Molecular Medicine and Chronic Diseases (ES)
- UK Dementia Research Institute (GB)
- University College London (GB)
Publication Details
- Journal
- Nature
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1038/s41586-026-10414-w
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00