SPP1+ macrophage-driven interactions shape the tumor microenvironment in lymph node metastatic acral melanoma
macrophage-driven immunosuppressive microenvironment and highlight the SPP1-CD44 axis as a promising therapeutic target for limiting AM dissemination.
Authors
- Maoqia Shen (ORCID: https://orcid.org/0009-0001-3290-7630)
- Fang Wang (ORCID: https://orcid.org/0000-0002-5971-2622)
- Zhimou Cai (ORCID: https://orcid.org/0000-0002-4250-8166)
- Zhangrui Shi
- Yuli Zheng
- Ruixin Yu
- Xiaolong Cao (ORCID: https://orcid.org/0000-0001-8124-7491)
- Yao Liang
Institutions
- Sun Yat-sen University (CN)
- Zhujiang Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Cell Death and Disease
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1038/s41419-026-08755-5
- Primary Topic
- Cutaneous Melanoma Detection and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00