CDKN2A/2B gene variants and gene-environment interactions increase the risk of gestational diabetes mellitus in Chinese women

Introduction: ) gene and gestational diabetes mellitus (GDM) in Chinese women, with a focus on potential gene-environment interactions. Methods: A case-control study was conducted with 1,566 pregnant women from Beijing, Wuhan, and Zunyi, China. Blood samples were analyzed using targeted next-generation sequencing. Logistic regression was applied to examine the relationship between gene polymorphisms, environmental exposures, and GDM. Gene-environment interactions were assessed using Excel tools developed by Knol and Andersson et al. Results: , further elevating GDM risk. Conclusion: , and gene-environment interactions contribute to an increased risk of GDM in Chinese women. Trial Registration: Chinese Clinical Trial Registry, chictr.org.cn, ChiCTR2000029178.