Hepatitis E virus-associated neurological injury and neurotropic cellular mechanisms
systems demonstrate that HEV can cross the blood-brain barrier (BBB) and replicate within neural tissues, providing biological plausibility for CNS involvement. By synthesizing clinical and experimental findings, this review highlights the dual pathogenic pathways underlying HEV-associated neurological injury and outlines key unresolved questions relevant to diagnosis, pathogenesis, and clinical management.
Authors
- Wenjiao Yin
- Minheng Cheng
- Xiujuan Peng
- Yuewei Tian
- Jijing Tian (ORCID: https://orcid.org/0000-0001-9005-8553)
- Yubing Ou
- Yanxin Hu
- Tianlong Liu
- Zixuan Guo
- Ruiping She
- Yaxin Sun
Institutions
- Department of Animal Health (VN)
- China Rural Technology Development Center (CN)
- National Institute for Viral Disease Control and Prevention (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-04-22
- DOI
- https://doi.org/10.3389/fcimb.2026.1810452
- Primary Topic
- Hepatitis Viruses Studies and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00