Integrating Recent Evidence and Expert Perspectives Into the Management of Multiple Myeloma: Consensus Recommendations From the 2025 Bridging the Gaps Conference

The rapid expansion of therapeutic options for multiple myeloma (MM) has created uncertainty regarding optimal sequencing and clinical application. To address gaps in evidence, the 2025 Bridging the Gaps Consensus Conference convened 16 US MM experts who reviewed data, debated controversies, and voted on 51 questions that were developed using a modified Delphi approach. Eleven consensus recommendations were developed spanning smoldering MM, frontline therapy, transplant, maintenance, and relapsed/refractory disease. Key themes included integration of quadruplet induction, individualized maintenance, and early referral for CAR-T therapy. These expert-derived recommendations provide practical guidance while highlighting areas requiring further investigation.

Authors

Institutions

Publication Details

Journal
American Journal of Hematology
Published
2026-04-21
DOI
https://doi.org/10.1002/ajh.70339
Primary Topic
Multiple Myeloma Research and Treatments
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Integrating Recent Evidence and Expert Perspectives Into the Management of Multiple Myeloma: Consensus Recommendations From the 2025 Bridging the Gaps Conference

Amrita Krishnan, Ajay K. Nooka, Darren Pan, Natalie S. Callander et al.
American Journal of Hematology
Multiple Myeloma Research and Treatments
article

Integrating Recent Evidence and Expert Perspectives Into the Management of Multiple Myeloma: Consensus Recommendations From the 2025 Bridging the Gaps Conference

Amrita Krishnan, Ajay K. Nooka, Darren Pan, Natalie S. Callander, Shambavi Richard, Doris K. Hansen, Jesús G. Berdeja, Noa Biran, Cristina Gasparetto, Binod Dhakal, Ajai Chari, Rahul Banerjee, Krina Patel, Anupama Kumar, Luciano J. Costa, Caitlin Costello
article en

Abstract

The rapid expansion of therapeutic options for multiple myeloma (MM) has created uncertainty regarding optimal sequencing and clinical application. To address gaps in evidence, the 2025 Bridging the Gaps Consensus Conference convened 16 US MM experts who reviewed data, debated controversies, and voted on 51 questions that were developed using a modified Delphi approach. Eleven consensus recommendations were developed spanning smoldering MM, frontline therapy, transplant, maintenance, and relapsed/refractory disease. Key themes included integration of quadruplet induction, individualized maintenance, and early referral for CAR-T therapy. These expert-derived recommendations provide practical guidance while highlighting areas requiring further investigation.

American Journal of Hematology
Hackensack University Medical Center (US), The University of Texas MD Anderson Cancer Center (US), Emory University (US), Duke University (US), University of California, San Francisco (US), Medical College of Wisconsin (US), Moffitt Cancer Center (US), University of Alabama at Birmingham (US), University of California San Diego (US), Fred Hutch Cancer Center (US), Piedmont Cancer Institute (US), University of Wisconsin Carbone Cancer Center (US), City of Hope (US), Tennessee Oncology (US), Icahn School of Medicine at Mount Sinai (US)
Openalex Percentile: Top 9%
Multiple Myeloma Research and Treatments
DOISourceOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.