A study on the structural and magnetic properties of Fe ₃ O ₄ @SiO ₂ core-shell microspheres along with a safety assessment in treating chemotherapy-resistant ovarian cancer

BACKGROUND: Ovarian cancer (OC) presents a significant challenge in the medical field due to its high mortality and resistance to chemotherapy. Chemoresistance in OC diminishes treatment efficacy and contributes to poor patient outcomes. Magnetic hyperthermia (MH) has demonstrated potential for addressing the chemoresistance of ovarian cancer (OC) directly through thermal effects. METHODS: nanoparticles and to investigate the underlying mechanism of magnetic hyperthermia. An animal subcutaneous xenograft model was used to investigate the safety and efficacy of magnetic fluid therapy under magnetic hyperthermia. RESULTS: magnetic fluid was successfully synthesized and several characterization experiments confirmed its good dispersion and magnetic properties. The target temperature of 50 °C can be reached within 5 min in the magnetic induction coil, and can be maintained at the target temperature for the subsequent time. Preclinical trials (animal model) validated MH's biocompatibility and tumor suppression capacity. CONCLUSION: experiments have confirmed that the magnetic fluid has good safety and excellent therapeutic effect under the magnetic induction coil.