A pressure relief valve for lysosomes
Several mechanisms repair damaged lysosomal membranes, but how can lysosomes prevent membrane failure in the first place? Kim et al. (https://doi.org/10.1083/jcb.202509180) uncover a rapid response whereby TMEM63A-dependent ion efflux relieves membrane tension, buying time for slower repair mechanisms to engage.
Authors
- Layla M. Nassar (ORCID: https://orcid.org/0000-0002-3080-7599)
- Shawn M. Ferguson (ORCID: https://orcid.org/0000-0002-3092-7718)
Institutions
- Yale University (US)
- Research Network (United States) (US)
Publication Details
- Journal
- The Journal of Cell Biology
- Published
- 2026-04-02
- DOI
- https://doi.org/10.1083/jcb.202604009
- Primary Topic
- Calcium signaling and nucleotide metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Michael J. Fox Foundation for Parkinson's Research
- Aligning Science Across Parkinson’s
- National Institutes of Health