Design, Synthesis and Biological Evaluation of Potent Piperazine-Based BioA Inhibitors Targeting Biotin Biosynthesis in <i>Mycobacterium tuberculosis</i>

Authors

Yahani P. Jayasinghe (ORCID: https://orcid.org/0000-0002-9313-8759)
Veronique Anne Dartois (ORCID: https://orcid.org/0000-0001-9470-5009)
Joshua B. Wallach
Dirk Schnappinger
Courtney C. Aldrich (ORCID: https://orcid.org/0000-0001-9261-594X)
Matthew D. Zimmerman (ORCID: https://orcid.org/0000-0002-6274-9493)
Donald R. Ronning (ORCID: https://orcid.org/0000-0003-2583-8849)
Jansy Passiflora Sarathy (ORCID: https://orcid.org/0000-0002-1532-146X)
Moyosore O. Orimoloye (ORCID: https://orcid.org/0000-0002-0330-008X)
Tsung-Yun Wong
Curtis A. Engelhart (ORCID: https://orcid.org/0000-0002-9324-5861)
Peng Ge (ORCID: https://orcid.org/0000-0002-2289-5373)
Suyapa Rodriguez

Institutions

University of Minnesota (US)
Cornell University (US)
Hackensack Meridian Health (US)
Center for Discovery (US)
University of Nebraska Medical Center (US)

Publication Details

Journal: Journal of Medicinal Chemistry
Published: 2026-04-22
DOI: https://doi.org/10.1021/acs.jmedchem.5c03325
Primary Topic: Biotin and Related Studies
Type: article
Field-Weighted Citation Impact: 0.00

Funders

National Institutes of Health
National Cancer Institute

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article

Design, Synthesis and Biological Evaluation of Potent Piperazine-Based BioA Inhibitors Targeting Biotin Biosynthesis in Mycobacterium tuberculosis

Yahani P. Jayasinghe, Veronique Anne Dartois, Joshua B. Wallach, Dirk Schnappinger et al.

Apr 22, 2026

Journal of Medicinal Chemistry

Biotin and Related Studies

article

Design, Synthesis and Biological Evaluation of Potent Piperazine-Based BioA Inhibitors Targeting Biotin Biosynthesis in Mycobacterium tuberculosis

Yahani P. Jayasinghe, Veronique Anne Dartois, Joshua B. Wallach, Dirk Schnappinger, Courtney C. Aldrich, Matthew D. Zimmerman, Donald R. Ronning, Jansy Passiflora Sarathy, Moyosore O. Orimoloye, Tsung-Yun Wong, Curtis A. Engelhart, Peng Ge, Suyapa Rodriguez

April 22, 2026article en

Abstract

No abstract available for this paper.

Journal of Medicinal Chemistry

University of Minnesota (US), Cornell University (US), Hackensack Meridian Health (US), Center for Discovery (US), University of Nebraska Medical Center (US)

National Institutes of Health, National Cancer Institute

Good health and well-being

Openalex Percentile: Top 15%

Biotin and Related Studies

DOI Source OpenAlex

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Design, Synthesis and Biological Evaluation of Potent Piperazine-Based BioA Inhibitors Targeting Biotin Biosynthesis in <i>Mycobacterium tuberculosis</i> — Yahani P. Jayasinghe, Veronique Anne Dartois, et al. · Journal of Medicinal Chemistry (2026) | TGRS Research Map | TGRS