Identification and Functional Analysis of Targets of Dehydrodiisoeugenol in Bladder Cancer Based on Chemoproteomics-Based Profiling
: These findings establish PTPN1 as a critical druggable vulnerability in bladder cancer and define the molecular basis for the therapeutic potential of DHE. This study highlights the power of combining chemoproteomics with physiological 3D models to accelerate the translation of natural products into precision cancer therapies.
Authors
- Bolin Jia (ORCID: https://orcid.org/0000-0003-3078-9287)
- Guoli Sheng
- Peng Du (ORCID: https://orcid.org/0000-0002-3466-8020)
- Yong Zhang
- Bin Jia
- Fan Wu
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Peking University Cancer Hospital (CN)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2026-04-21
- DOI
- https://doi.org/10.3390/ph19040651
- Primary Topic
- Medicinal plant effects and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences