An improved method for high-purity isolation of oligodendrocytes from neonatal and adult mouse brain
cells proliferated and differentiated into MBP- and QKI7-positive oligodendrocytes. This approach provides a practical platform for studying oligodendrocyte biology and evaluating therapeutic vectors and other interventions in myelin disorders.
Authors
- Peiyi Guo
- Guangping Gao (ORCID: https://orcid.org/0000-0003-0097-9012)
- Dominic J. Gessler (ORCID: https://orcid.org/0000-0003-0067-7444)
- Elisabet C. Mandon (ORCID: https://orcid.org/0000-0001-9616-3469)
- Morgan Mooney
- Paula Vo (ORCID: https://orcid.org/0000-0002-1988-2168)
- Jessica B. Spinelli (ORCID: https://orcid.org/0000-0003-3657-4578)
- Keith Reddig
- Anoushka Lotun
- Jie Wang
- Madison C. Jerome
Institutions
- Howard Hughes Medical Institute (US)
- Nanjing Normal University (CN)
- University of Massachusetts Chan Medical School (US)
Publication Details
- Journal
- iScience
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1016/j.isci.2026.115841
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Neurological Disorders and Stroke