Rhodomyrtus tomentosa fruit ameliorates LPS induced depression-like behaviors in mice by attenuating hippocampal neuroinflammation via inhibiting the TLR4/MyD88/MAPK/NF-κB/NLRP3 signaling pathway

Introduction: fruit is a dietary food with various bioactivities. However, the comprehensive mechanisms underlying its antidepressant effects remain be fully understood. Methods: (RTEE) on depression-like behaviors in lipopolysaccharide (LPS)-challenged mice, and to explore the molecular basis. Results: experiments using microglial BV2 cells showed that RTEE significantly rescued cell viability and reduced NO production via suppressing the NF-κB signaling pathway. Discussion: fruit may serve as a novel nutritional intervention for depression.