Single Cell and Bulk RNA-Seq Profiling of Non-Metastatic Versus Bone-Metastatic Prostate Cancer Identifies the CXCL10-CXCR3 Axis as a Key Determinant of Tumor Microenvironment and Treatment Resistance
These findings uncover a context-dependent endothelial-immune chemokine network distinguishing non-metastatic from bone-metastatic PCa and identify the CXCL10-CXCR3 axis as a critical mediator of tumor survival and chemoresistance, suggesting a potential therapeutic vulnerability in advanced prostate cancer.
Authors
- Zaixu Zhao
- Linxiong Ye
- Xinxing Du (ORCID: https://orcid.org/0009-0001-3437-0021)
- Liu Y (ORCID: https://orcid.org/0009-0004-3901-1652)
- Zijian Song
- Kaidi Jin
- Jiyuan Yu
- Likai Ren
- Wei Zhou
- Hong Wang
- Yanqing Wang
- Wei Xue
- Qi Zhang
Institutions
- Jiangsu University (CN)
- Jiangsu Normal University (CN)
- Shanghai Medical College of Fudan University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Renji Hospital (CN)
- Xuzhou Cancer Hospital (CN)
Publication Details
- Journal
- Biomedicines
- Published
- 2026-04-21
- DOI
- https://doi.org/10.3390/biomedicines14040943
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Beijing Xisike Clinical Oncology Research Foundation
- National Natural Science Foundation of China
- Shanghai Jiao Tong University
- State Administration of Traditional Chinese Medicine of the People's Republic of China
- Xuzhou Medical University
- Renji Hospital
- School of Medicine, Shanghai Jiao Tong University