Cancer‐Associated Fibroblast‐Derived Sphingosine‐1‐Phosphate Activates a MALL–SDC4 Axis to Facilitate Perineural Invasion in Pancreatic Cancer
; Pdx1-Cre) mice significantly reduces PNI and tumor burden. These findings uncover a metabolite-driven MALL-SDC4 program connecting stromal metabolism to neural invasion, and identify promising therapeutic targets for PDAC.
Authors
- Mengdie Cao (ORCID: https://orcid.org/0000-0001-6773-3952)
- Luoxia Liu
- Shuya Bai (ORCID: https://orcid.org/0009-0003-9333-0817)
- Shiru Chen
- Zhou Luan (ORCID: https://orcid.org/0009-0008-0692-2862)
- Yuchong Zhao (ORCID: https://orcid.org/0000-0003-2245-8541)
- Wang Peng (ORCID: https://orcid.org/0009-0009-3447-3598)
- Bin Cheng (ORCID: https://orcid.org/0000-0003-1568-8760)
- Jiamei Jiang (ORCID: https://orcid.org/0000-0002-6969-1917)
- Luyao Liu (ORCID: https://orcid.org/0000-0001-5241-967X)
- Haochen Cui
- Jingwen Liang (ORCID: https://orcid.org/0009-0000-7973-2818)
- Si Xiong
- Q Zhou
- H T Huang
- Ronghua Wang
- Wei Chen
Institutions
- Mercy Medical Center (US)
- Shandong Provincial Hospital (CN)
- University of Pittsburgh Medical Center (US)
- Tongji Hospital (CN)
- Shandong First Medical University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Advanced Science
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1002/advs.75426
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China