Time-dependent diffusion MRI differentiates atypical from conventional uterine leiomyomas: A preliminary study

Background: Preoperative differentiation of atypical from conventional uterine leiomyomas remains challenging on routine MRI due to overlapping morphological characteristics and signal heterogeneity related to degeneration or necrosis. Purpose: -dMRI) derived from oscillating and pulsed gradient spin-echo (OGSE/PGSE) sequences improves differentiation between atypical and conventional uterine leiomyomas compared with routine MRI (T1WI, T2WI and DWI). Materials and methods: -dMRI modelling. Group differences were assessed using independent-sample tests, and diagnostic performances were evaluated with generalized linear models (GLMs) and receiver operating characteristic (ROC) analyses. Results: = 0.0075). Conclusion: -dMRI may serve as a promising adjunct for preoperative characterization and treatment planning of uterine leiomyomas.