Comorbid Alzheimer's Disease and Type 2 Diabetes Microbiota Shape Age‐Associated Gut–Brain Axis Profiles
= 0.028, p = 0.006), suggesting transmission of aging-associated microbial signatures. Hippocampal neurotrophic gene expression was most suppressed in AD+T2DM recipients (adjusted p value < 0.05) and negatively correlated with disease- and aging-associated taxa and microbial functions (|r| > 0.4, FDR p < 0.05). AD recipients showed reduced olfactory discrimination and increased daytime locomotor activity. Metabolic network analysis revealed depletion of flavonoid, isoflavonoid, and lignan biosynthesis pathways in disease recipients. These findings suggest that microbiota from elderly donors with comorbid AD+T2DM may induce gut-brain axis alterations, linking aging, metabolic dysfunction, and neurodegeneration through convergent taxonomic, functional, and neurotrophic changes. We underscore the potential role of age-associated gut microbial signatures in modulating neurobiological outcomes.
Authors
- Aurelijus Burokas (ORCID: https://orcid.org/0000-0002-0364-3496)
- Rokas Lukoševičius (ORCID: https://orcid.org/0000-0003-4584-9828)
- Greta Najūtė
- Alessandro Atzeni (ORCID: https://orcid.org/0000-0002-1804-8606)
- Justinas Drūteika
- Kasper Sipowicz (ORCID: https://orcid.org/0000-0001-7384-2899)
- Karolina Keršytė
- Gediminas Alzbutas (ORCID: https://orcid.org/0000-0002-5958-0543)
- Daiva Baltriukienė (ORCID: https://orcid.org/0000-0002-7851-9270)
- Juozas Kupčinskas (ORCID: https://orcid.org/0000-0002-8760-7416)
- Jordi Mayneris‐Perxachs (ORCID: https://orcid.org/0000-0003-3788-3815)
- Rima Ramonaitė (ORCID: https://orcid.org/0000-0001-5093-9305)
- Jonas Mingaila (ORCID: https://orcid.org/0009-0006-5214-0189)
- Tadeusz Pietras (ORCID: https://orcid.org/0000-0003-1771-3819)
- Dovilė Kiudelytė
- Emilija Keževičiūtė
- Kamila Łuczyńska
Institutions
- Lithuanian University of Health Sciences (LT)
- Vilnius University (LT)
- Hospital of Lithuanian University of Health Sciences Kaunas Clinics (LT)
- Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences (PL)
- Institut d'Investigació Biomèdica de Girona (ES)
- Medical University of Lodz (PL)
- The Maria Grzegorzewska University (PL)
- Institute of Psychiatry and Neurology (PL)
Publication Details
- Journal
- Aging Cell
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1111/acel.70488
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Lietuvos Mokslo Taryba