The <scp>MacBrain</scp> Resource Center ( <scp>MBRC</scp> ) rhesus macaque embryonic brain histology datasets
H-TdR) cases in MBRC Collection 1 and the electron microscopy (EM) blocks of Collection 5, which together contain >100 specimens of different developmental ages. We also report methodological details on, as of July 2025, n = 24 histo- and immunohistochemically processed embryonic brains that enrich Collection 6 with thousands of coronal sections stained for n = 38 different cellular and fiber markers. These datasets provide NHP brain histo- and immunohistology for comparison with other species and hence help close a gap in the availability of suitable materials for comparative evolution and neurodevelopmental studies. Through examples, we illustrate how different materials are currently being used in de novo research. Finally, we advocate the absolute need to continue using NHPs in the study of neurodevelopment because of the unparalleled molecular, genetic, and anatomical similarities between these animal models and humans.
Authors
- Lucy Greene
- Željka Krsnik (ORCID: https://orcid.org/0000-0001-5238-6820)
- Pasko Rakić (ORCID: https://orcid.org/0000-0002-6963-0508)
- Phil Barello
- Yury M. Morozov (ORCID: https://orcid.org/0000-0002-3679-6819)
- Keiko Moriya‐Ito (ORCID: https://orcid.org/0009-0006-1689-0337)
- Chiaki Ohtaka‐Maruyama (ORCID: https://orcid.org/0000-0002-0632-7341)
- Janja Kopić (ORCID: https://orcid.org/0000-0002-4545-1329)
- Alvaro Duque (ORCID: https://orcid.org/0000-0002-5086-5438)
- Valeria Mendoza-Silva
- Mikhail Rodov (ORCID: https://orcid.org/0009-0009-9570-242X)
Institutions
- University of Zagreb (HR)
- Yale University (US)
- Tokyo Metropolitan Institute of Medical Science (JP)
Publication Details
- Journal
- Journal of Anatomy
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1111/joa.70161
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hrvatska Zaklada za Znanost
- National Institutes of Health