The <scp>MacBrain</scp> Resource Center ( <scp>MBRC</scp> ) rhesus macaque embryonic brain histology datasets

H-TdR) cases in MBRC Collection 1 and the electron microscopy (EM) blocks of Collection 5, which together contain >100 specimens of different developmental ages. We also report methodological details on, as of July 2025, n = 24 histo- and immunohistochemically processed embryonic brains that enrich Collection 6 with thousands of coronal sections stained for n = 38 different cellular and fiber markers. These datasets provide NHP brain histo- and immunohistology for comparison with other species and hence help close a gap in the availability of suitable materials for comparative evolution and neurodevelopmental studies. Through examples, we illustrate how different materials are currently being used in de novo research. Finally, we advocate the absolute need to continue using NHPs in the study of neurodevelopment because of the unparalleled molecular, genetic, and anatomical similarities between these animal models and humans.

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Publication Details

Journal
Journal of Anatomy
Published
2026-04-21
DOI
https://doi.org/10.1111/joa.70161
Primary Topic
Single-cell and spatial transcriptomics
Type
article
Field-Weighted Citation Impact
0.00

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article

The MacBrain Resource Center ( MBRC ) rhesus macaque embryonic brain histology datasets

Lucy Greene, Željka Krsnik, Pasko Rakić, Phil Barello et al.
Journal of Anatomy
Single-cell and spatial transcriptomics
article

The MacBrain Resource Center ( MBRC ) rhesus macaque embryonic brain histology datasets

Lucy Greene, Željka Krsnik, Pasko Rakić, Phil Barello, Yury M. Morozov, Keiko Moriya‐Ito, Chiaki Ohtaka‐Maruyama, Janja Kopić, Alvaro Duque, Valeria Mendoza-Silva, Mikhail Rodov
article en

Abstract

H-TdR) cases in MBRC Collection 1 and the electron microscopy (EM) blocks of Collection 5, which together contain >100 specimens of different developmental ages. We also report methodological details on, as of July 2025, n = 24 histo- and immunohistochemically processed embryonic brains that enrich Collection 6 with thousands of coronal sections stained for n = 38 different cellular and fiber markers. These datasets provide NHP brain histo- and immunohistology for comparison with other species and hence help close a gap in the availability of suitable materials for comparative evolution and neurodevelopmental studies. Through examples, we illustrate how different materials are currently being used in de novo research. Finally, we advocate the absolute need to continue using NHPs in the study of neurodevelopment because of the unparalleled molecular, genetic, and anatomical similarities between these animal models and humans.

Journal of Anatomy
University of Zagreb (HR), Yale University (US), Tokyo Metropolitan Institute of Medical Science (JP)
Hrvatska Zaklada za Znanost, National Institutes of Health
Openalex Percentile: Top 11%
Single-cell and spatial transcriptomics
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